Total synthesis of (±)-Wortmannin

被引：53

作者：

Mizutani, T ^{[1
]}

Honzawa, S ^{[1
]}

Tosaki, S ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

Heck reaction; natural products; phosphoinositide; 3-kinase; rearrangement; total synthesis;

D O I：

10.1002/anie.200290014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A potent and specific phosphoinositide 3-kinase inhibitor (±)-wortmannin has been achieved through an intramolecular Heck reaction for the construction of an allylic quaternary carbon center and a diosphenol-Claisen rearrangement (see scheme). SEM = 2-(Trimethylsilyl)ethoxymethyl.

引用

页码：4680 / +

页数：4

共 23 条

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