Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis

被引：106

作者：

Liang, PH

Cheng, WC

Lee, YL

Yu, HP

Wu, YT

Lin, YL

Wong, CH

机构：

[1] Acad Sinica, Genom Res Ctr, Taipei 11529, Taiwan

[2] Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 01期

关键词：

antiviral agents; glycoproteins; iminocyclitols; inhibitors; osteoarthritis;

D O I：

10.1002/cbic.200500321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a K-i value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (K-i = 2.6 rim), a new target for the development of osteoarthritis therapeutics.

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收藏

页码：165 / 173

页数：9

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