Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures

被引:101
作者
TalSinger, R
Lasner, TM
Podrzucki, W
Skokotas, A
Leary, JJ
Berger, SL
Fraser, NW
机构
[1] HOSP UNIV PENN,WISTAR INST,PHILADELPHIA,PA 19104
[2] HOSP UNIV PENN,DIV NEUROSURG,PHILADELPHIA,PA 19104
[3] SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL VIROL & HOST DEF,COLLEGEVILLE,PA
关键词
D O I
10.1128/JVI.71.7.5268-5276.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Herpes simplex virus (HSV) replicates in peripheral tissues and forms latent infections in neurons of the peripheral nervous system, It can be reactivated from latency by various stimuli to cause recurrent disease, During lytic infection in tissue culture cells, there is a well-described temporal pattern of ii) immediate-early, (ii) early, and (iii) late gene expression, However, latency is characterized by little if any expression of genes of the lytic cycle of infection. During reactivation, the pattern of gene expression is presumed to be similar to that during the lytic cycle in tissue culture, though recent work of W. P. Halford ct al, (J. Virol. 70:5051-5060, 1996) and P. F. Nichol et al. (J. Virol. 70:5476-5 186, 1996) suggests that it is modified in neuronal cell cultures, We have used the mouse trigeminal ganglion explant model and reverse transcription-PCR to determine the pattern of viral and cellular gene expression during reactivation, Surprisingly, the pattern of viral gene expression during lytic infection of tell cultures is not seen during reactivation. During reactivation, early viral transcripts were detected before immediate-early transcripts. The possibility that a cellular factor upregulates early genes during the initial reactivation stimulus is discussed.
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页码:5268 / 5276
页数:9
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