Transition metals in organic synthesis -: Part 83#:: Synthesis and pharmacological potential of carbazoles

被引：105

作者：

Choi, Taylor A. ^{[1
,2
]}

Czerwonka, Regina ^{[1
]}

Forke, Ronny ^{[1
]}

Jaeger, Anne ^{[1
]}

Knoell, Jan ^{[1
]}

Krahl, Micha P. ^{[1
]}

Krause, Tilo ^{[1
]}

Reddy, Kethiri R. ^{[1
]}

Franzblau, Scott G. ^{[2
]}

Knoelker, Hans-Joachim ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany

[2] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA

来源：

MEDICINAL CHEMISTRY RESEARCH | 2008年 / 17卷 / 2-7期

关键词：

D O I：

10.1007/s00044-007-9073-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of carbazole derivatives with promising pharmacological properties has been prepared using either an iron-mediated or a palladium-catalyzed synthetic approach. The carbazole alkaloids carbazoquinocin C, carbazomadurin A and B, epocarbazolin A and B, neocarazostatin B, and carquinostatin A are antioxidants acting as free-radical scavengers. Thus, they represent potential lead compounds for the development of novel drugs against diseases initiated by oxygen-derived free radicals. Initiated by the first naturally occurring carbazole alkaloids with antituberculosis (anti-TB) activity, clausine K and micromeline, a study on the structure-activity relationships for anti-TB-active carbazole derivatives has been carried out. The 6-oxygenated carbazoles glycozoline and glycozolinine show antibiotic activity towards several microorganisms. The 7-oxygenated carbazole siamenol exhibits anti-HIV activity.

引用

页码：374 / 385

页数：12

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