Preeclampsia, Placenta, Oxidative Stress, and PMCA

被引：35

作者：

Abad, Cilia ^{[1
]}

Proverbio, Teresa ^{[1
]}

Pinero, Sandy ^{[1
]}

Botana, Desiree ^{[1
]}

Chiarello, Delia I. ^{[1
]}

Marin, Reinaldo ^{[1
]}

Proverbio, Fulgencio ^{[1
]}

机构：

[1] Inst Venezolano Invest Cient, CBB, Lab Bioenerget Celular, Caracas 1020A, Venezuela

来源：

HYPERTENSION IN PREGNANCY | 2012年 / 31卷 / 04期

关键词：

Calcium; Preeclampsia; Placenta; Oxidative stress; PMCA; PLASMA-MEMBRANE CA2+-ATPASE; ADENOSINE-TRIPHOSPHATASE ACTIVITY; CALCIUM-ATPASE ACTIVITY; RED-BLOOD-CELLS; LIPID-PEROXIDATION; MAGNESIUM-SULFATE; NORMAL-PREGNANCY; CA-ATPASE; HUMAN MYOMETRIUM; NULL MUTATION;

D O I：

10.3109/10641955.2012.690058

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.

引用

页码：427 / 441

页数：15

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