Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum

被引：41

作者：

Chen, Li-Li ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
,3
,4
]}

Li, Man-Mei ^{[1
,2
]}

Ou, Guo-Min ^{[1
,2
]}

Zhao, Bing-Xin ^{[1
,2
]}

Chen, Min-Feng ^{[1
,2
]}

Zhang, Qing-Wen ^{[3
,4
]}

Wang, Ying ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[3] Univ Macau, State Key Lab Qual Res Chinese Med, Taipa, Peoples R China

[4] Univ Macau, Inst Chinese Med Sci, Taipa, Macao Sar, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 04期

关键词：

Polygonum multiflorum; Flavanostilbene; Stilbene glycoside; Polygonflavanol A; Anti-inflammatory; ABSOLUTE-CONFIGURATION; CIRCULAR-DICHROISM; CONSTITUENTS; PRODUCTS;

D O I：

10.1016/j.phytol.2012.08.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Polygonflavanol A (1), a novel flavonostilbene glycoside with an unusual coupling pattern, together with five known stilbene glycosides (2-6), was isolated from the roots of Polygonum multiflorum. The structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidence. The absolute configuration of 1 was further determined by CD analysis. Most of the compounds could inhibit nitric oxide (NO) secretion of RAW264.7 cells in respond to lipopolysaccharide (LPS) in a dose dependent manner. Among them, compound 2 displayed the highest inhibitory activity. (c) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：756 / 760

页数：5

共 25 条

[1]

[Anonymous], 1993, Basic One- and Two-dimensional NMR Spectroscopy

[2]

Ayers S, 2008, NAT PROD COMMUN, V3, P189

[3]

Chen W., 2000, Acta Pharm. Sin., V35, P273

[4]

Chen W.S., 1999, ACAD J 2 MIL MED U, V20, P438