Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation

被引：66

作者：

Tanimoto, Koichi ^{[2
]}

Tomita, Haruyoshi ^{[1
]}

Fujimoto, Shuhei ^{[1
]}

Okuzumi, Katsuko ^{[3
]}

Ike, Yasuyoshi ^{[1
,2
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Bacteriol, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Lab Bacteria Drug Resistance, Gunma 3718511, Japan

[3] Dokkyo Med Univ Hosp, Dept Safety Med, Adm Div Infect Control, Shimotsuga, Tochigi 3210293, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 10期

关键词：

D O I：

10.1128/AAC.00464-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

引用

页码：3795 / 3800

页数：6

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