Contribution of non-reference alleles in mtDNA of Alzheimer's disease patients

被引：15

作者：

Casoli, Tiziana ^{[1
]}

Di Stefano, Giuseppina ^{[1
,6
]}

Spazzafumo, Liana ^{[2
]}

Balietti, Marta ^{[3
]}

Giorgetti, Belinda ^{[1
]}

Giuli, Cinzia ^{[4
]}

Postacchini, Demetrio ^{[4
]}

Fattoretti, Patrizia ^{[3
]}

Conti, Fiorenzo ^{[1
,5
]}

机构：

[1] INRCA IRCCS, Ctr Neurobiol Aging, Via Birarelli 8, I-60121 Ancona, Italy

[2] INRCA IRCCS, Ctr Biostat, I-60124 Ancona, Italy

[3] INRCA IRCCS, Ctr Neurobiol Aging, Cellular Bioenerget Lab, I-60121 Ancona, Italy

[4] INRCA IRCCS Hosp, Unit Geriatr, I-63023 Fermo, Italy

[5] Univ Politecn Marche, Dept Expt & Clin Med, Sect Neurosci & Cell Biol, I-60126 Ancona, Italy

[6] INRCA IRCCS, Sci Direct, I-60124 Ancona, Italy

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2014年 / 1卷 / 04期

关键词：

D O I：

10.1002/acn3.42

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Many observations suggest that mutations of mitochondrial DNA (mtDNA) could be responsible for the neurodegenerative changes of Alzheimer's disease (AD). Here we examined the signal intensity of the four alleles of each mtDNA nucleotide position (np) in whole blood of AD patients and age-matched controls using MitoChip v2.0 array. Our analysis identified 270 significantly different nps which, with one exception, showed an increased contribution of non-reference alleles in AD patients. Principal component analysis (PCA) and cluster analysis showed that five of these nps could discriminate AD from control subjects with 80% of cases correctly classified. Our data support the hypothesis of mtDNA alterations as an important factor in the etiology of AD.

引用

页码：284 / 289

页数：6

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