Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis

被引：49

作者：

Aoki, Yuta ^{[1
,2
]}

Orikabe, Lina ^{[1
]}

Takayanagi, Yoichiro ^{[2
]}

Yahata, Noriaki ^{[1
]}

Mozue, Yuriko ^{[2
]}

Sudo, Yasuhiko ^{[2
]}

Ishii, Tatsuji ^{[3
]}

Itokawa, Masanari ^{[4
]}

Suzuki, Michio ^{[5
]}

Kurachi, Masayoshi ^{[5
]}

Okazaki, Yuji ^{[2
]}

Kasai, Kiyoto ^{[1
]}

Yamasue, Hidenori ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, Tokyo 1560057, Japan

[3] Tokyo Metropolitan Matsuzawa Hosp, Dept Radiol, Setagaya Ku, Tokyo 1560057, Japan

[4] Tokyo Metropolitan Inst Med Sci, Setagaya Ku, Tokyo 1568506, Japan

[5] Toyama Univ, Dept Neuropsychiat, Grad Sch Med & Pharmaceut Sci, Sugitani, Toyama 9300194, Japan

来源：

SCHIZOPHRENIA RESEARCH | 2013年 / 147卷 / 2-3期

关键词：

Brain; Brodmann area (BA) 10; Frontal pole; Human; Stimulant; Substance use; GRAY-MATTER VOLUME; VOXEL-BASED MORPHOMETRY; ANTISOCIAL PERSONALITY-DISORDER; SUPERIOR TEMPORAL GYRUS; 1ST-EPISODE SCHIZOPHRENIA; AMPHETAMINE PSYCHOSIS; LIKELIHOOD ESTIMATION; PSYCHIATRIC-SYMPTOMS; MRI; METAANALYSIS;

D O I：

10.1016/j.schres.2013.04.029

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Consumption of methamphetamine disturbs dopaminergic transmission and sometimes provokes schizophrenia-like-psychosis, named methamphetamine-associated psychosis (MAP). While previous studies have repeatedly reported regional volume reductions in the frontal and temporal areas as neuroanatomical substrates for psychotic symptoms, no study has examined whether such neuroanatomical substrates exist or not in patients with MAP. Magnetic resonance images obtained from twenty patients with MAP and 20 demographically-matched healthy controls (HC) were processed for voxel-based morphometry (VBM) using Diffeomorphic Anatomical Registration using Exponentiated Lie Algebra. An analysis of covariance model was adopted to identify volume differences between subjects with MAP and HC, treating intracranial volume as a confounding covariate. The VBM analyses showed significant gray matter volume reductions in the left perisylvian structures, such as the posterior inferior frontal gyrus and the anterior superior temporal gyrus, and the frontopolar cortices, including its dorsomedial, ventromedial, dorsolateral, and ventrolateral portions, and white matter volume reduction in the orbitofrontal area in the patients with MAP compared with the HC subjects. The smaller regional gray matter volume in the medial portion of the frontopolar cortex was significantly correlated with the severe positive symptoms in the individuals with MAP. The volume reductions in the left perisylvian structure suggest that patients with MAP have a similar pathophysiology to schizophrenia, whereas those in the frontopolar cortices and orbitofrontal area suggest an association with antisocial traits or vulnerability to substance dependence. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：355 / 361

页数：7

共 68 条

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