Cyclin e overexpression reduces infiltrative growth in breast cancer - Yet another link between proliferation control and tumor invasion

被引：21

作者：

Berglund, Pontus ^{[1
]}

Landberg, Goran ^{[1
]}

机构：

[1] Lund Univ, Malmo Univ Hosp, Dept Lab Med, Malmo 20502, Sweden

来源：

CELL CYCLE | 2006年 / 5卷 / 06期

关键词：

breast cancer; cyclin E; invasion; proliferation; medullary breast cancer; microarray;

D O I：

10.4161/cc.5.6.2569

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

引用

页码：606 / 609

页数：4

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