The synthesis and characterization of new triphenylethylene platinum(II) complexes

被引：12

作者：

Berube, G

He, YH

Groleau, S

Sene, A

Therien, HM

Caron, M

机构：

[1] Dept. de Chimie-biologie, Univ. Quebec Trois-Rivieres, C.P., Trois-Rivières

来源：

INORGANICA CHIMICA ACTA | 1997年 / 262卷 / 02期

基金：

英国医学研究理事会;

关键词：

platinum complexes; triphenylethylene complexes; cytotoxic complexes;

D O I：

10.1016/S0020-1693(97)05514-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In our search for a chemotherapeutic agent with a better therapeutic index and selectivity for the treatment of breast cancer, we have synthesized a series of cytotoxic analogs of tamoxifen. The new triphenylethylene platinum(II) derivatives were designed to possess binding affinity for the estrogen receptor. The synthesis of this type of compound is straightforward and efficient. The new complexes were fully characterized by their IR, H-1 NMR and C-13 NMR spectra as well as their elemental analysis. The estrogen receptor binding affinity (RBA) of some of these triphenylethylenes was also evaluated and was found to be comparable to the affinity of the reference drug, i.e, tamoxifen, RBA=1.3%.

引用

页码：139 / 145

页数：7

共 39 条

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