Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells

被引：23

作者：

Du, HY

Olivo, M

Tan, BKH

Bay, BH

机构：

[1] Natl Univ Singapore, Dept Anat, Fac Med, Singapore 117597, Singapore

[2] Natl Canc Ctr, Dept Med Sci, Singapore 169610, Singapore

[3] Natl Univ Singapore, Dept Pharmacol, Fac Med, Singapore 117597, Singapore

来源：

CANCER LETTERS | 2004年 / 207卷 / 02期

基金：

英国医学研究理事会;

关键词：

nasopharyngeal carcinoma; photodynamic therapy; glutathione S-transferase; reactive oxygen species; confocal microscopy;

D O I：

10.1016/j.canlet.2003.12.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：175 / 181

页数：7

共 26 条

[1] Hypericin in cancer treatment: more light on the way [J].