Enantioselective aza-Diels-Alder reaction catalyzed by a chiral Bronsted acid: Effect of the additive on the enantioselectivity

被引：130

作者：

Akiyama, T ^{[1
]}

Tamura, Y ^{[1
]}

Itoh, J ^{[1
]}

Morita, H ^{[1
]}

Fuchibe, K ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

SYNLETT | 2006年 / 01期

关键词：

asymmetric synthesis; chiral Bronsted acid; aza-Diels-Alder reaction; Danishefsky's diene;

D O I：

10.1055/s-2005-922773

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Danishefsky's diene and aldimine underwent aza Diels-Alder reaction under the influence of chiral phosphoric;acid derived from (R)-BINOL as a chiral Bronsted acid to afford piperidinone derivatives in good to high enantioselectivity. Addition of CH,CO,H improved both reactivity and enantioselectivity.

引用

收藏

页码：141 / 143

页数：3

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