The neurochemical profile quantified by in vivo 1H NMR spectroscopy

被引：179

作者：

Duarte, Joao M. N. ^{[1
,2
]}

Lei, Hongxia ^{[1
,3
]}

Mlynarik, Vladimir ^{[1
]}

Gruetter, Rolf ^{[1
,2
,3
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Funct Metab Imaging, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Dept Radiol, CH-1015 Lausanne, Switzerland

[3] Univ Geneva, Dept Radiol, CH-1211 Geneva 4, Switzerland

来源：

NEUROIMAGE | 2012年 / 61卷 / 02期

关键词：

Neurochemical profile; NMR spectroscopy; Brain; MAGNETIC-RESONANCE-SPECTROSCOPY; AMYOTROPHIC-LATERAL-SCLEROSIS; PROTON MR SPECTROSCOPY; HUMAN VISUAL-CORTEX; MILD COGNITIVE IMPAIRMENT; VITAMIN-C-DEFICIENCY; CEREBRAL GLUCOSE-CONCENTRATIONS; CHLORALOSE-ANESTHETIZED RATS; EMBRYONIC-DEVELOPMENT ALTERS; GAMMA-AMINOBUTYRIC-ACID;

D O I：

10.1016/j.neuroimage.2011.12.038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by H-1 NMR spectroscopy define the so-called "neurochemical profile". The non-invasive quality of this technique makes it suitable not only for diagnostic purposes but also for therapy monitoring paralleling an eventual neuroprotection. The application of H-1 NMR spectroscopy in basic and translational neuroscience research is discussed here. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：342 / 362

页数：21

共 343 条

[1] QUANTITATIVE-ANALYSIS OF COMPLICATED NONIDEAL FOURIER-TRANSFORM NMR-SPECTRA [J].

ABILDGAARD, F ;

GESMAR, H ;

LED, JJ .

JOURNAL OF MAGNETIC RESONANCE, 1988, 79 (01) :78-89

[2] A geometrically adjustable 16-channel transmit/receive transmission line array for improved RF efficiency and parallel imaging performance at 7 Tesla [J].

Adriany, Gregor ;

De Moortele, Pierre-Francois Van ;

Ritter, Johannes ;

Moeller, Steen ;

Auerbach, Edward J. ;

Akguen, Can ;

Snyder, Carl J. ;

Vaughan, Thomas ;

Ugurbill, Kamil .

MAGNETIC RESONANCE IN MEDICINE, 2008, 59 (03) :590-597

[3] Taurine interaction with neurotransmitter receptors in the CNS: An update [J].

Albrecht, J ;

Schousboe, A .

NEUROCHEMICAL RESEARCH, 2005, 30 (12) :1615-1621

[4] Choline availability during embryonic development alters the localization of calretinin in develovina and aaina mouse hippocampus [J].

Albright, CD ;

Siwek, DF ;

Craciunescu, CN ;

Mar, MH ;

Kowall, NW ;

Williams, CL ;

Zeisel, SH .

NUTRITIONAL NEUROSCIENCE, 2003, 6 (02) :129-134

[5] High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice [J].

Alf, Malte F. ;

Lei, Hongxia ;

Berthet, Carole ;

Hirt, Lorenz ;

Gruetter, Rolf ;

Mlynarik, Vladimir .

NMR IN BIOMEDICINE, 2012, 25 (02) :247-254

[6] Measurement of Glutathione in Normal Volunteers and Stroke Patients at 3T Using J-Difference Spectroscopy with Minimized Subtraction Errors [J].

An, Li ;

Zhang, Yan ;

Thomasson, David M. ;

Latour, Lawrence L. ;

Baker, Eva H. ;

Shen, Jun ;

Warach, Steven .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 30 (02) :263-270

[7] SYNCHRONOUS DEVELOPMENT OF PYRAMIDAL NEURON DENDRITIC SPINES AND PARVALBUMIN-IMMUNOREACTIVE CHANDELIER NEURON AXON TERMINALS IN LAYER-III OF MONKEY PREFRONTAL CORTEX [J].

ANDERSON, SA ;

CLASSEY, JD ;

CONDE, F ;

LUND, JS ;

LEWIS, DA .

NEUROSCIENCE, 1995, 67 (01) :7-22

[8] Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation [J].

Andreassen, OA ;

Jenkins, BG ;

Dedeoglu, A ;

Ferrante, KL ;

Bogdanov, MB ;

Kaddurah-Daouk, R ;

Beal, MF .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (02) :383-390

[9]

Angelie E, 2001, AM J NEURORADIOL, V22, P119

[10] Improved Homogeneity of the Transmit Field by Simultaneous Transmission with Phased Array and Volume Coil [J].

Avdievich, Nikolai I. ;

Oh, Sukhoon ;

Hetherington, Hoby P. ;

Collins, Christopher M. .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 32 (02) :476-481

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