Functional analysis of an aspartate-based epoxidation catalyst with amide-to-alkene peptidomimetic catalyst analogues

被引：108

作者：

Jakobsche, Charles E. ^{[1
]}

Peris, Gorka ^{[1
]}

Miller, Scott J. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 35期

关键词：

asymmetric catalysis; epoxidation; fluorine; olefin isostere; peptides; peptidomimetic;

D O I：

10.1002/anie.200802223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：6707 / 6711

页数：5

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