Deletion mapping of 18q in conventional renal cell carcinoma

被引：21

作者：

Hirata, H ^{[1
]}

Matsuyama, H ^{[1
]}

Matsumoto, H ^{[1
]}

Korenaga, Y ^{[1
]}

Ohmi, C ^{[1
]}

Sakano, S ^{[1
]}

Yoshihiro, S ^{[1
]}

Naito, K ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Urol, Yamaguchi 7558505, Japan

来源：

CANCER GENETICS AND CYTOGENETICS | 2005年 / 163卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2005.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Loss of heterozygosity (LOH) is frequently associated with the inactivation of tumor suppressor genes. 18q LOH has been frequently reported in colorectal cancer and lung cancer; however, allelic loss on 18q has not been investigated in renal cell carcinoma (RCC). We evaluated LOH on 18q using nine microsatellite markers in 126 with conventional RCC (cRCC). LOH was observed in more than one 18q microsatellite locus in 24 cRCC (19%). We found the highest frequency of LOH (13.5%) at 18q21.3, where the DCC gene is located. We also assessed the relationship between LOH frequency and patient clinical parameters. Patients with a family history of cancer had a significantly higher frequency of 18q LOH than those without such a history (P = 0.0017). No associations were found with other parameters, including gender, tumor grade, tumor stage, smoking status, and body mass index. The results suggest that inactivation of tumor suppressor genes at 18q21.3, including DCC and SMAD4 as candidates, may be involved in the tumorigenesis of some conventional RCCs. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：101 / 105

页数：5

共 32 条

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