Agonist-activated ion channels

被引：26

作者：

Colquhoun, D ^{[1
]}

机构：

[1] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2006年 / 147卷

关键词：

ion channel; single channel; receptor; acetylcholine; glycine receptor; history;

D O I：

10.1038/sj.bjp.0706502

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens.

引用

收藏

页码：S17 / S26

页数：10

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