Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study

被引：47

作者：

Fontes, Joao D. ^{[1
,2
]}

Yamamoto, Jennifer F. ^{[1
]}

Larson, Martin G. ^{[1
,3
]}

Wang, Na ^{[3
]}

Dallmeier, Dhayana ^{[1
,4
]}

Rienstra, Michiel ^{[1
,5
]}

Schnabel, Renate B. ^{[1
,6
]}

Vasan, Ramachandran S. ^{[1
,2
,7
]}

Keaney, John F., Jr. ^{[8
]}

Benjamin, Emelia J. ^{[1
,2
,7
]}

机构：

[1] Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA

[2] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Cardiol Sect, Boston, MA 02118 USA

[3] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA

[4] Boston Univ, Sch Med, Div Gen Internal Med, Boston, MA 02118 USA

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[6] Johannes Gutenberg Univ Mainz, Dept Med 2, D-55122 Mainz, Germany

[7] Boston Univ, Sch Med, Dept Med, Prevent Med Sect, Boston, MA 02118 USA

[8] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA USA

来源：

ATHEROSCLEROSIS | 2013年 / 228卷 / 01期

关键词：

Biological markers; Longitudinal studies; Inflammation; C-REACTIVE PROTEIN; PERIPHERAL ARTERIAL-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PLASMA-CONCENTRATION; PHOSPHOLIPASE A(2); OXIDATIVE STRESS; ADHESION MOLECULE-1; ADIPOSE-TISSUE; BLOOD-PRESSURE;

D O I：

10.1016/j.atherosclerosis.2013.01.019

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives: Traditional clinical risk factors are associated with inflammation cross-sectionally, but associations of longitudinal variation in inflammatory biomarkers with corresponding changes in clinical risk factors are incompletely described. We sought to analyze clinical factors associated with change in inflammation in the community. Methods: We studied 3013 Framingham Offspring (n = 2735) and Omni Cohort (n = 278) participants (mean age 59 years, 55% women, 9% ethnic/racial minority) who attended two consecutive examination cycles (mean 6.7 years apart). We selected ten inflammatory biomarkers representing distinctive biological functions: C-reactive protein (CRP), intercellular adhesion molecule-1, interleukin-6, isoprostanes, lipoprotein-associated phospholipase-2 (Lp-PLA2) activity, Lp-PLA2-mass, monocyte chemoattractant protein-1, osteoprotegerin, P-selectin, and tumor necrosis factor receptor II (TNFRII). We constructed multivariable-adjusted regression models to assess the relations of baseline, follow-up and change in clinical risk factors with change in biomarker concentrations over time. Results: Baseline, follow-up and change in clinical risk factors explain a moderate amount of the variation in biomarker concentrations across 2 consecutive examinations (ranging from r(2) = 0.28 [TNFRII] up to 0.52 [Lp-PLA2-mass]). In multivariable models, increasing body-mass index, smoking initiation, worsening lipid profile, and increasing waist size were associated with increasing concentrations of several biomarkers. Conversely, hypercholesterolemia therapy and hormone replacement cessation were associated with decreasing concentrations of biomarkers such as CRP, Lp-PLA2-mass and activity. Conclusion: Cardiovascular risk factors have different patterns of association with longitudinal change in inflammatory biomarkers and explain modest amounts of variability in biomarker concentrations. Nevertheless, a substantial proportion of longitudinal change in inflammatory markers is not explained by traditional risk factors. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：217 / 223

页数：7

共 51 条

[1]

Inflammation as a risk factor for atrial fibrillation [J].

Aviles, RJ ;

Martin, DO ;

Apperson-Hansen, C ;

Houghtaling, PL ;

Rautaharju, P ;

Kronmal, RA ;

Tracy, RP ;

Van Wagoner, DR ;

Psaty, BM ;

Lauer, MS ;

Chung, MK .

CIRCULATION, 2003, 108 (24) :3006-3010

[2]

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence [J].

Bautista, LE .

JOURNAL OF HUMAN HYPERTENSION, 2003, 17 (04) :223-230

[3]

Long-term C-Reactive Protein Variability and Prediction of Metabolic Risk [J].

Chen, Ting-hsu ;

Gona, Philimon ;

Sutherland, Patrice A. ;

Benjamin, Emelia J. ;

Wilson, Peter W. F. ;

Larson, Martin G. ;

Vasan, Ramachandran S. ;

Robins, Sander J. .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (01) :53-61

[4]

Evaluation of the association between the first observation and the longitudinal change in C-reactive protein, and all-cause mortality [J].

Currie, C. J. ;

Poole, C. D. ;

Conway, P. .

HEART, 2008, 94 (04) :457-462

[5]

National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants [J].

Danaei, Goodarz ;

Finucane, Mariel M. ;

Lin, John K. ;

Singh, Gitanjali M. ;

Paciorek, Christopher J. ;

Cowan, Melanie J. ;

Farzadfar, Farshad ;

Stevens, Gretchen A. ;

Lim, Stephen S. ;

Riley, Leanne M. ;

Ezzati, Majid ;

Abdeen, Ziad ;

Agyemang, Charles ;

Al Nsour, Mohannad ;

Ali, Mohamed M. ;

Ambady, Ramachandran ;

Babu, Bontha V. ;

Barbagallo, Carlo M. ;

Barcelo, Alberto ;

Barreto, Sandhi M. ;

Barros, Henrique ;

Bautista, Leonelo E. ;

Bjerregaard, Peter ;

Bjoerkelund, Cecilia ;

Bo, Simona ;

Bobak, Martin ;

Bonora, Enzo ;

Botana, Manuel A. ;

Bovet, Pascal ;

Breckenkamp, Juergen ;

Breteler, Monique M. ;

Broda, Grazyna ;

Brown, Ian J. ;

Bursztyn, Michael ;

de Leon, Antonio Cabrera ;

Casiglia, Edoardo ;

Castetbon, Katia ;

Chatterji, Somnath ;

Chen, Zhengming ;

Chen, Chien-Jen ;

Chua, Lily ;

Cifkova, Renata ;

Cobiac, Linda J. ;

Cooper, Richard S. ;

Dankner, Rachel S. ;

Dong, Guang-Hui ;

Elliott, Paul ;

Erem, Cihangir ;

Esteghamati, Alireza ;

Fan, Jian-Gao .

LANCET, 2011, 377 (9765) :568-577

[6]

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels [J].

Dehghan, Abbas ;

Dupuis, Josee ;

Barbalic, Maja ;

Bis, Joshua C. ;

Eiriksdottir, Gudny ;

Lu, Chen ;

Pellikka, Niina ;

Wallaschofski, Henri ;

Kettunen, Johannes ;

Henneman, Peter ;

Baumert, Jens ;

Strachan, David P. ;

Fuchsberger, Christian ;

Vitart, Veronique ;

Wilson, James F. ;

Pare, Guillaume ;

Naitza, Silvia ;

Rudock, Megan E. ;

Surakka, Ida ;

de Geus, Eco J. C. ;

Alizadeh, Behrooz Z. ;

Guralnik, Jack ;

Shuldiner, Alan ;

Tanaka, Toshiko ;

Zee, Robert Y. L. ;

Schnabel, Renate B. ;

Nambi, Vijay ;

Kavousi, Maryam ;

Ripatti, Samuli ;

Nauck, Matthias ;

Smith, Nicholas L. ;

Smith, Albert V. ;

Sundvall, Jouko ;

Scheet, Paul ;

Liu, Yongmei ;

Ruokonen, Aimo ;

Rose, Lynda M. ;

Larson, Martin G. ;

Hoogeveen, Ron C. ;

Freimer, Nelson B. ;

Teumer, Alexander ;

Tracy, Russell P. ;

Launer, Lenore J. ;

Buring, Julie E. ;

Yamamoto, Jennifer F. ;

Folsom, Aaron R. ;

Sijbrands, Eric J. G. ;

Pankow, James ;

Elliott, Paul ;

Keaney, John F. .

CIRCULATION, 2011, 123 (07) :731-U151

[7]

Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women - A randomized trial [J].

Esposito, K ;

Pontillo, A ;

Di Palo, C ;

Giugliano, G ;

Masella, M ;

Marfella, R ;

Giugliano, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (14) :1799-1804

[8]

National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants [J].

Farzadfar, Farshad ;

Finucane, Mariel M. ;

Danaei, Goodarz ;

Pelizzari, Pamela M. ;

Cowan, Melanie J. ;

Paciorek, Christopher J. ;

Singh, Gitanjali M. ;

Lin, John K. ;

Stevens, Gretchen A. ;

Riley, Leanne M. ;

Ezzati, Majid .

LANCET, 2011, 377 (9765) :578-586

[9]

The relation of body fat mass and distribution to markers of chronic inflammation [J].

Festa, A ;

D'Agostino, R ;

Williams, K ;

Karter, AJ ;

Mayer-Davis, EJ ;

Tracy, RP ;

Haffner, SM .

INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (10) :1407-1415

[10]

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants [J].

Finucane, Mariel M. ;

Stevens, Gretchen A. ;

Cowan, Melanie J. ;

Danaei, Goodarz ;

Lin, John K. ;

Paciorek, Christopher J. ;

Singh, Gitanjali M. ;

Gutierrez, Hialy R. ;

Lu, Yuan ;

Bahalim, Adil N. ;

Farzadfar, Farshad ;

Riley, Leanne M. ;

Ezzati, Majid .

LANCET, 2011, 377 (9765) :557-567

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