Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

被引：17

作者：

Eckle, Sidonia B. G. ^{[1
]}

Turner, Stephen J. ^{[1
]}

Rossjohn, Jamie ^{[2
,3
]}

McCluskey, James ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[3] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF14 4XN, S Glam, Wales

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 05期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

MAJOR HISTOCOMPATIBILITY COMPLEX; VITAMIN-B METABOLITES; BULGED VIRAL PEPTIDE; GERMLINE BIAS; SELF; ALLORECOGNITION; RESTRICTION; POPULATION; SELECTION; OBSESSION;

D O I：

10.1016/j.coi.2013.07.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The diverse alpha beta T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern alpha beta TCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.

引用

页码：653 / 659

页数：7

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