Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran

被引：86

作者：

Badali, Hamid ^{[1
,2
]}

Vaezi, Afsane ^{[1
]}

Haghani, Iman ^{[1
]}

Yazdanparast, Seyed A. ^{[3
]}

Hedayati, Mohammad T. ^{[1
,2
]}

Mousavi, Bita ^{[1
]}

Ansari, Saham ^{[1
]}

Hagen, Ferry ^{[4
]}

Meis, Jacques F. ^{[4
,5
]}

Chowdhary, Anuradha ^{[6
]}

机构：

[1] Mazandaran Univ Med Sci, Sch Med, Invas Fungi Res Ctr IFRC, Dept Med Mycol & Parasitol, Sari, Iran

[2] Mazandaran Univ Med Sci, Sch Med, Mol & Cell Biol Res Ctr MCBRC, Sari, Iran

[3] Iran Univ Med Sci, Sch Allied Med, Dept Med Parasitol & Mycol, Tehran, Iran

[4] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, NL-6500 GS Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[6] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007, India

来源：

MYCOSES | 2013年 / 56卷 / 06期

关键词：

Aspergillus fumigatus; cyp51A; TR34/L98H; azole resistance; Iran; microsatellite typing; TR/L98H MUTATION; PREVALENCE;

D O I：

10.1111/myc.12089

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.

引用

页码：659 / 663

页数：5

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