Who and where is the renal baroreceptor?: the connexin hypothesis

被引：18

作者：

Gomez, R. Ariel ^{[1
]}

Lopez, Maria Luisa S. Sequeira ^{[1
]}

机构：

[1] Univ Virginia, Dept Pediat, Med Ctr, Charlottesville, VA 22908 USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 75卷 / 05期

关键词：

RENIN; CELLS; EXPRESSION; SECRETION; PRESSURE; KIDNEY;

D O I：

10.1038/ki.2008.536

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin.

引用

收藏

页码：460 / 462

页数：3

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