Detection and localization of surgically resectable cancers with a multi-analyte blood test

被引：2468

作者：

Cohen, Joshua D. ^{[1
,2
,3
,4
,5
]}

Li, Lu ^{[6
]}

Wang, Yuxuan ^{[1
,2
,3
,4
]}

Thoburn, Christopher ^{[3
]}

Afsari, Bahman ^{[7
]}

Danilova, Ludmila ^{[7
]}

Douville, Christopher ^{[1
,2
,3
,4
]}

Javed, Ammar A. ^{[8
]}

Wong, Fay ^{[1
,3
,4
]}

Mattox, Austin ^{[1
,2
,3
,4
]}

Hruban, Ralph. H. ^{[3
,4
,9
]}

Wolfgang, Christopher L. ^{[8
]}

Goggins, Michael G. ^{[3
,4
,9
,10
,11
]}

Dal Molin, Marco ^{[4
]}

Wang, Tian-Li ^{[3
,9
]}

Roden, Richard ^{[3
,9
]}

Klein, Alison P. ^{[1
,3
,4
,12
]}

Ptak, Janine ^{[1
,2
,3
,4
]}

Dobbyn, Lisa ^{[1
,3
,4
]}

Schaefer, Joy ^{[1
,3
,4
]}

Silliman, Natalie ^{[1
,2
,3
,4
]}

Popoli, Maria ^{[1
,3
,4
]}

Vogelstein, Joshua T. ^{[13
]}

Browne, James D. ^{[14
]}

Schoen, Robert E. ^{[15
,16
]}

Brand, Randall E. ^{[15
]}

Tie, Jeanne ^{[17
,18
,19
,20
]}

Gibbs, Peter ^{[17
,18
,19
,20
]}

Wong, Hui-Li ^{[17
]}

Mansfield, Aaron S. ^{[21
]}

Jen, Jin ^{[22
]}

Hanash, Samir M. ^{[23
]}

Falconi, Massimo ^{[24
]}

Allen, Peter J. ^{[25
]}

Zhou, Shibin ^{[1
,3
,4
]}

Bettegowda, Chetan ^{[1
,3
,4
]}

Diaz, Luis A., Jr. ^{[1
,3
,4
,26
]}

Tomasetti, Cristian ^{[3
,6
,7
]}

Kinzler, Kenneth W. ^{[1
,3
,4
]}

Vogelstein, Bert ^{[1
,2
,3
,4
]}

Lennon, Anne Marie ^{[3
,4
,8
,10
,11
]}

Papadopoulos, Nickolas ^{[1
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA

[7] Johns Hopkins Med Inst, Dept Oncol, Div Biostat & Bioinformat, Baltimore, MD 21287 USA

[8] Johns Hopkins Med Inst, Dept Surg, Baltimore, MD 21287 USA

[9] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21287 USA

[10] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21287 USA

[11] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21287 USA

[12] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[13] Johns Hopkins Univ, Sch Med, Inst Computat Med, Baltimore, MD 21205 USA

[14] Johns Hopkins Univ, Whiting Sch Engn, Dept Comp Sci, Baltimore, MD 21218 USA

[15] Univ Pittsburgh, Dept Med, 930 Scaife Hall, Pittsburgh, PA 15260 USA

[16] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15260 USA

[17] Walter & Eliza Hall Inst Med Res, Div Syst Biol & Personalized Med, Parkville, Vic 3021, Australia

[18] Univ Melbourne, Fac Med Dent & Hlth Sci, Melbourne, Vic 3010, Australia

[19] Western Hlth, Dept Med Oncol, Melbourne, Vic 3021, Australia

[20] Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic 3000, Australia

[21] Mayo Clin, Dept Oncol, Div Med Oncol, Rochester, MN 55902 USA

[22] Mayo Clin, Dept Lab Med & Pathol, Div Expt Pathol, Rochester, MN 55902 USA

[23] Univ Texas MD Anderson Canc Ctr, Sheikh Ahmed Ctr Pancreat Canc Res, Houston, TX 77030 USA

[24] Res Hosp, San Raffaele Sci Inst, Dept Surg, Div Pancreat Surg, I-20132 Milan, Italy

[25] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA

[26] Mem Sloan Kettering Canc Ctr, Div Solid Tumor Oncol, New York, NY 10065 USA

来源：

SCIENCE | 2018年 / 359卷 / 6378期

基金：

美国国家卫生研究院;

关键词：

CIRCULATING TUMOR DNA; QUANTIFICATION; BIOMARKERS; MUTATIONS;

D O I：

10.1126/science.aar3247

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

引用

页码：926 / +

页数：5

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