BAG6/BAT3: emerging roles in quality control for nascent polypeptides

被引：77

作者：

Kawahara, Hiroyuki ^{[1
,2
]}

Minami, Ryosuke ^{[1
,2
]}

Yokota, Naoto ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Dept Biol Sci, Lab Cell Biol & Biochem, Hachioji, Tokyo 1920397, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Biochem, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2013年 / 153卷 / 02期

关键词：

chaperonin; MHC; proteasome; scythe; ubiquitin; TAIL-ANCHORED PROTEINS; SCYTHE REGULATES APOPTOSIS; MOLECULAR CHAPERONES; MEMBRANE INSERTION; UBIQUITIN LIGASE; BAT3; PROMOTES; CELL-DEATH; MHC; COMPLEX; DEGRADATION;

D O I：

10.1093/jb/mvs149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T-cell response. Recent studies have shown that BAG6 is essential for the quality control of aggregation-prone polypeptide biogenesis. It forms part of a complex that determines the fate of newly synthesized client proteins for membrane insertion, ubiquitin-mediated degradation and/or aggregate formation. A biologically relevant transmembrane protein family has recently been shown to be a major client of BAG6, suggesting that many of the known diverse BAG6 functions can be interpreted by BAG6-mediated control of membrane protein biogenesis. In this review, we summarize the current understanding of the physiological roles of BAG6 with a particular focus on quality control for nascent chain polypeptides.

引用

页码：147 / 160

页数：14

共 100 条

[1]

A GENE PAIR FROM THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX ENCODES LARGE PROLINE-RICH PROTEINS WITH MULTIPLE REPEATED MOTIFS AND A SINGLE UBIQUITIN-LIKE DOMAIN [J].