Adoptive immunotherapy: good habits instilled at youth have long-term benefits

被引：34

作者：

Paulos, Chrystal M. ^{[1
]}

Suhoski, Megan M. ^{[1
]}

Plesa, Gabriela ^{[1
]}

Jiang, Tianying ^{[1
]}

Basu, Samik ^{[1
]}

Golovina, Tatiana N. ^{[1
]}

Jiang, Shuguang ^{[1
]}

Aqui, Nicole A. ^{[1
,2
]}

Powell, Daniel J., Jr. ^{[1
]}

Levine, Bruce L. ^{[1
,2
]}

Carroll, Richard G. ^{[1
]}

Riley, James L. ^{[1
,2
]}

June, Carl H. ^{[1
,2
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 42卷 / 1-3期

关键词：

Adoptive cell transfer therapy; Artificial antigen presenting cells; Regulatory T cells; Th17; Cells; Central Memory T cells;

D O I：

10.1007/s12026-008-8070-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many recent advances in basic cell biology and immunology are a harbinger of progress in adoptive cell therapy (ACT) including (1) the finding that host lymphodepletion enhances engraftment and efficacy, (2) the recognition that in vitro T cell functions may not correlate with in vivo efficacy, and (3) the development of advanced ex vivo culture methods to expand lymphocytes to therapeutically effective numbers. In this article, we focus on the development of artificial antigen presenting cells (aAPCs) in our laboratory and their applicability to augment ACT protocols. We also describe how aAPCs can be used to broaden ACT to treat patients with a wide variety of cancers, chronic infectious diseases, and autoimmune manifestations.

引用

页码：182 / 196

页数：15

共 78 条

[1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[2]

Almand B, 2000, CLIN CANCER RES, V6, P1755

[3] CD8+T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells [J].

Antony, PA ;

Piccirillo, CA ;

Akpinarli, A ;

Finkelstein, SE ;

Speiss, PJ ;

Surman, DR ;

Palmer, DC ;

Chan, CC ;

Klebanoff, CA ;

Overwijk, WW ;

Rosenberg, SA ;

Restifo, NP .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2591-2601

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5] Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin [J].

Basu, Samik ;

Golovina, Tatiana ;

Mikheeva, Tatiana ;

June, Carl H. ;

Riley, James L. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (09) :5794-5798

[6] Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [J].

Battaglia, M ;

Stabilini, A ;

Roncarolo, MG .

BLOOD, 2005, 105 (12) :4743-4748

[7] Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates [J].

Berger, Carolina ;

Jensen, Michael C. ;

Lansdorp, Peter M. ;

Gough, Mike ;

Elliott, Carole ;

Riddell, Stanley R. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :294-305

[8]

Bertozzi CC, 2006, IN VITRO CELL DEV-AN, V42, P58

[9] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[10] TH-17 cells in the circle of immunity and autoimmunity [J].

Bettelli, Estelle ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2007, 8 (04) :345-350

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