Lupus nephritis

被引：20

作者：

Agrawal, N ^{[1
]}

Chiang, LK ^{[1
]}

Rifkin, IR ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

SEMINARS IN NEPHROLOGY | 2006年 / 26卷 / 02期

关键词：

lupus; nephritis; autoimmunity;

D O I：

10.1016/j.semnephrol.2005.09.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lupus nephritis is one of the more serious manifestations of the systemic autoimmune disease, systemic lupus erythematosus, and is associated with considerable morbidity and even mortality. Treatment remains problematic, particularly in terms of controlling the underlying disease process while at the same time preventing unacceptable side effects of therapy. In recent years, clinical trials have started to define optimum regimens of the immunosuppressive agents presently in use. The etiology and pathogenesis of systemic lupus erythematosus and lupus nephritis still are understood incompletely. Nevertheless, insights gained from basic science research in both animals and human beings now are being translated into newer therapies that have the potential to be safer and more specific than those currently available. © 2006 Elsevier Inc. All rights reserved.

引用

页码：95 / 104

页数：10

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