Effects of near-infra-red laser irradiation on adenosine triphosphate and adenosine diphosphate contents of rat brain tissue

被引:118
作者
Mochizuki-Oda, N [1 ]
Kataoka, Y
Cui, YL
Yamada, H
Heya, M
Awazu, K
机构
[1] Osaka Univ, Grad Sch Engn, Inst Free Electron Laser, Osaka 5730128, Japan
[2] Kansai Med Univ, Dept Anat & Cell Sci, Osaka 5708506, Japan
[3] Osaka City Univ, Grad Sch Med, Dept Physiol, Osaka 5458585, Japan
关键词
near-infra-red laser; pain relief; brain; adenosine triphosphate; thermal effect; energy metabolism;
D O I
10.1016/S0304-3940(02)00159-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Low-power, near-infra-red laser irradiation has been used to relieve patients from various kinds of pain, though the precise mechanisms of such biological actions of the laser halve not yet been resolved. To investigate the cellular mechanisms by near-infra-red laser on the nervous system, we examined the effect of 830-nm laser irradiation on the energy metabolism of the rat brain. The diode laser was applied for 15 min with an irradiance of 4.8 W/cm(2). Tissue adenosine triphosphate (ATP) content of the irradiated area in the cerebral cortex was 19% higher than that of the non-treated area, whereas the adenosine diphosphate (ADP) content showed no significant difference. Laser irradiation at another wavelength (652 nm) had no effect on either ATIP or ADP contents. The temperature of the tissue was increased by 4.4-4.7 degreesC during the irradiation of both wavelengths. These results suggest that the increase in tissue ATP content did not result from the thermal effect, but from a specific effect of the laser operated at the 830-nm wavelength. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:207 / 210
页数:4
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