Convergent synthesis of the E′FGH′ ring fragment of ciguatoxin 1B via an acetylene cobalt complex strategy

被引：43

作者：

Takai, SY ^{[1
]}

Isobe, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Nagoya, Aichi 4648601, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1021/ol0256264

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A convergent synthesis of the E'FGH' ring fragment of ciguatoxin has been accomplished through (i) coupling between the E' ring-acetylide and the H' ring-aldehyde, (ii) stereoselective F ring cyclization via an acetylene cobalt complex, (iii) conversion to a carbonyl function, and (iv) reductive hydroxy-ketone cyclization to construct the G ring.

引用

页码：1183 / 1186

页数：4

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