Serum allograft inflammatory factor-1 is a novel marker for diabetic nephropathy

被引：30

作者：

Fukui, Michiaki ^{[1
]}

Tanaka, Muhei ^{[1
]}

Asano, Mai ^{[1
]}

Yamazaki, Masahiro ^{[1
]}

Hasegawa, Goji ^{[1
]}

Imai, Saeko ^{[2
]}

Fujinami, Aya ^{[3
]}

Ohta, Mitsuhiro ^{[3
]}

Obayashi, Hiroshi ^{[4
]}

Nakamura, Naoto ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, Kyoto 6028566, Japan

[2] Osaka Prefecture Univ, Fac Comprehens Rehabil, Dept Clin Nutr, Osaka, Japan

[3] Kobe Pharmaceut Univ, Dept Med Biochem, Hyogo, Japan

[4] Inst Bioresponse Informat, Kyoto, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2012年 / 97卷 / 01期

关键词：

Macrophage; Albuminuria; Chronic kidney disease; RENAL INJURY; MACROPHAGES; EXPRESSION; PENTOXIFYLLINE; INFILTRATION; ASSOCIATION; PROTEIN-1; OBESITY;

D O I：

10.1016/j.diabres.2012.04.009

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Aims: Recent studies have identified macrophage-mediated injury as an important component in the development of diabetic nephropathy. The aim of this study was to investigate the correlations between serum allograft inflammatory factor-1 (AIF-1) concentration, which is a marker of activated macrophages, and diabetic nephropathy. Methods: Serum AIF-1 concentrations were measured in 284 patients with type 2 diabetes. We evaluated relationships of serum AIF-1 concentrations to degree of urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in univariate and multivariate linear regression analyses. Results: Serum AIF-1 concentrations positively correlated with logarithm of UAE (r = 0.260, P < 0.0001), whereas serum AIF-1 concentrations inversely correlated with eGFR (r = -0.312, P < 0.0001). Mean serum AIF-1 concentration was higher in patients with macroalbuminuria than that in patients with normoalbuminuria (P = 0.0001) or that in patients with microalbuminuria (P = 0.0093). In multivariate linear regression analyses, serum AIF-1 concentrations were independently correlated with logarithm of UAE (beta = 0.213, P = 0.0120) and with ;eGFR (beta = -0.286, P = 0.0011). Conclusions: Serum AIF-1 concentration correlated with albuminuria and eGFR in patients with type 2 diabetes and it could be a marker of diabetic nephropathy as well as activated macrophages. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：146 / 150

页数：5

共 29 条

[1]

A Review of the Potential Benefits of Pentoxifylline in Diabetic and Non-Diabetic Proteinuria [J].