Detection of low levels of flunitrazepam and its metabolites in blood and bloodstains

被引：18

作者：

Elian, AA ^{[1
]}

机构：

[1] Commonwealth Massachusetts, Forens Toxicol Lab, Sudbury, MA 01776 USA

来源：

FORENSIC SCIENCE INTERNATIONAL | 1999年 / 101卷 / 02期

关键词：

toxicology; flunitrazepam; solid-phase extraction; GC-MS;

D O I：

10.1016/S0379-0738(99)00013-4

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Detection of low levels of flunitrazepam and its metabolites was developed using solid-phase extraction to isolate the drugs from whole liquid blood and dried bloodstains, with subsequent derivatization with pentafluoropropionic anhydride (PFPA) followed by N-(tert-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) with 1% TBDMSCI. Analysis was confirmed by gas chromatography/mass spectroscopy using select ion monitoring (sim) in electron impact mode. The limit of detection of this procedure using 1 mi of blood was determined to be 0.1 mu g/dl. (C) 1999 Elsevier Science Ire:land Ltd. All rights reserved.

引用

页码：107 / 111

页数：5

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