Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay

被引：34

作者：

Ito, C

Itoigawa, M ^{[1
]}

Furukawa, H

Tokuda, H

Okuda, Y

Mukainaka, T

Okuda, M

Nishino, H

机构：

[1] Tokyo Gakugei Univ, Miyoshi, Aichi 4700207, Japan

[2] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 1999年 / 138卷 / 1-2期

关键词：

anti-tumor-promoting effect; Epstein-Barr virus activation test; 8-substituted; 7-methoxycoumarins; structure-activity relationships;

D O I：

10.1016/S0304-3835(98)00376-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a search for anti-tumour-promoting agents, we carried out a primary screening of twenty-nine 8-substituted and four 6-substituted derivatives of 7-methoxycoumarins isolated from plants of the Murraya and/or Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. This investigation indicated that the prenyl (3-methyl-2-butenyl) or 2-hydroxy-3-methylbutyl (or butenyl) unit as an isoprenoid moiety at C-8 on the 7-methoxycoumarin nucleus plays an important role in the anti-tumor-promoting activity. Some of the 8-substituted 7-methoxycoumarins isolated from Murraya species, murrangatin (7), minumicrolin (10) and chloticol (18), were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that 7, 10 and 18 might be valuable anti-tumor-promoting agents. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：87 / 92

页数：6

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