Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus

被引：49

作者：

Han, JunJie ^{[1
,2
]}

Chen, YuHui ^{[3
]}

Bao, Li ^{[1
]}

Yang, XiaoLi ^{[1
]}

Liu, Dailin ^{[4
]}

Li, ShaoJie ^{[1
]}

Zhao, Feng ^{[5
]}

Liu, Hongwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Southwest Forestry Univ, Coll Life Sci, Kunming 650224, Peoples R China

[4] Chinese Peoples Armed Police Forces, Dept Pharmacognosy, Logist Coll, Tianjin 300162, Peoples R China

[5] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

来源：

FITOTERAPIA | 2013年 / 84卷

关键词：

Cyathus africanus; Cyathane diterpenes; Structure elucidation; Cytotoxicity; NO inhibition; BIRDS NEST FUNGI; GROWTH-FACTOR (NGF)-SYNTHESIS; HERICIUM-ERINACEUM; FRUITING BODIES; NITRIC-OXIDE; BITTER DITERPENOIDS; SARCODON-SCABROSUS; METABOLITES; MYCELIA; MUSHROOM;

D O I：

10.1016/j.fitote.2012.10.001

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Five novel cyathane diterpenes, cyathins D-H (1-5), as well as three known diterpenes, neosarcodonin O (6), cyathatriol (7),and 11-O-acetylcyathatriol (8), were isolated from the solid culture of Cyathus africanus. The structures of the new compounds were elucidated by spectroscopic methods. The absolute configurations of compounds 2 and 8 were determined by single-crystal X-ray crystallographic analysis, whereas the absolute configuration of C-14 in 1 was determined via the circular dichroism data of the [Rh-2(OCOCF3)(4)] complex. Compounds 3, 5, 6, 8, and 9 showed potent inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 2.57, 1.45, 12.0, 10.73, and 9.45 mu M, respectively. Compounds 6 and 8 showed strong cytotoxicity against Hela and K562 cell lines with the IC50 value less than 10 mu M. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：22 / 31

页数：10

共 46 条

[1]

[Anonymous], 2015, Acta Crystallogr., V71, P3

[2]

DITERPENOID METABOLITES OF CYATHUS-HELENAE - CYATHIN-B3 AND CYATHIN-C3 [J].