The N-terminal domain of SV40 large T antigen represses the HER2/neu-mediated transformation and metastatic potential in breast cancers

被引：8

作者：

Chuang, TC

Yu, YH

Lin, YS

Wang, SS

Kao, MC ^{[1
]}

机构：

[1] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan

[2] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan

[3] Adpharma Inc, Dept Res & Dev, Tainan, Taiwan

来源：

FEBS LETTERS | 2002年 / 511卷 / 1-3期

关键词：

HER2/neu; p185; metastasis; simian virus 40 large T antigen;

D O I：

10.1016/S0014-5793(01)03277-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HER2/neu is known to be overexpressed in approximately. 40% of human breast and ovarian cancers and it is associated with increased metastasis and poor prognosis. We have shown previously that the N-terminal domain of simian virus 40 large T antigen (LT425) can act as a transforming suppressor of the HER21neu oncogene in human ovarian cancer. In the present study, we demonstrate that LT425 can also repress the transforming properties of HER2/neu-overexpressing human breast cancer cells. In addition, the results of a chemotaxis assay and an in vitro chemoinvasion assay further suggest that LT425 can also suppress the metastatic potential of the HER2/neu-transformed breast cancer cells. Taken together, these data clearly suggest that the inhibition of the expression of p185(HER2/neu) tyrosine kinase by LT425 is capable of suppressing the HER2/neu-mediated transformation and metastatic potential in breast cancers. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：46 / 50

页数：5

共 39 条

[1]

ALBINI A, 1987, CANCER RES, V47, P3239

[2] THE NEU ONCOGENE ENCODES AN EPIDERMAL GROWTH-FACTOR RECEPTOR-RELATED PROTEIN [J].