Melatonin suppresses hyperglycemia caused by intracerebroventricular injection of 2-deoxy-D-glucose in rats

被引：31

作者：

Shima, T

Chun, SJ

Niijima, A

BizotEspiard, JG

GuardiolaLemaitre, B

Hosokawa, M

Nagai, K

机构：

[1] OSAKA UNIV, INST PROT RES, DIV PROT METAB, SUITA, OSAKA 565, JAPAN

[2] NIIGATA UNIV, SCH MED, NIIGATA 951, JAPAN

[3] INST RECH INT SERVIER, F-92415 COURBEVOIE, FRANCE

[4] CNRS, UPRESA 5018, F-31054 TOULOUSE, FRANCE

来源：

NEUROSCIENCE LETTERS | 1997年 / 226卷 / 02期

关键词：

glucose; glucagon; insulin; brain; antagonist;

D O I：

10.1016/S0304-3940(97)00257-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To elucidate the role of melatonin (MT), we examined the effects of intracranial injection of MT and an MT-antagonist (S20928) on the hyperglycemic response to intracranial injection of 2-deoxy-D-glucose (2DG) in rats. The hyperglycemic and hyperglucagonemic responses caused by intracerebroventricular injection of 2DG were inhibited by intracerebroventricular co-injection of MT, but enhanced by coinjection of the MT-antagonist. Intraperitoneal injection of MT also inhibited the hyperglycemic response, though the inhibition seemed to be less than that after intracranial injection of MT. These results suggest that MT plays an endogenously suppressive role in the hyperglycemia caused by 2DG, possibly through a brain site. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：119 / 122

页数：4

共 7 条

[1] EFFECTS OF MELATONIN ON VERTEBRATE CIRCADIAN SYSTEMS [J].

CASSONE, VM .

TRENDS IN NEUROSCIENCES, 1990, 13 (11) :457-464

[2]

CHUN SJ, 1994, NEUROSCI LETT, V175, P157

[3]

DELAGRANGE P, 1995, NATO ADV SCI INST SE, V277, P139

[4]

LeGouic S, 1996, INT J OBESITY, V20, P661

[5] SCN output drives the autonomic nervous system: With special reference to the autonomic function related to the regulation of glucose metabolism [J].

Nagai, K ;

Nagai, N ;

Shimizu, K ;

Chun, S ;

Nakagawa, H ;

Niijima, A .

HYPOTHALAMIC INTEGRATION OF CIRCADIAN RHYTHMS, 1996, 111 :253-272

[6] Bilateral lesions of the hypothalamic suprachiasmatic nucleus eliminated sympathetic response to intracranial injection of 2-deoxy-D-glucose and VIP rescued this response [J].

Nagai, K ;

Niijima, A ;

Nagai, N ;

Hibino, H ;

Chun, SJ ;

Shimizu, K ;

Nakagawa, H .

BRAIN RESEARCH BULLETIN, 1996, 39 (05) :293-297

[7]

SADASHIMA S, 1979, AM J PHYSIOL, V241, pH78

← 1 →