Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid

被引：98

作者：

Verrotti, A

Basciani, F

Morresi, S

de Martino, M

Morgese, G

Chiarelli, F

机构：

[1] Univ Chieti, Dept Med, Sect Pediat, Chieti, Italy

[2] Univ Siena, Dept Pediat, I-53100 Siena, Italy

来源：

NEUROLOGY | 1999年 / 53卷 / 01期

关键词：

D O I：

10.1212/WNL.53.1.230

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Weight gain has been recognized as an adverse effect of valproic acid therapy, but there are are no data about serum leptin levels in patients receiving this drug. To evaluate if valproic acid treatment in epileptic patients in whom obesity develops modifies serum levels of insulin and leptin, 40 female patients with epilepsy were evaluated before therapy and after 1 year of therapy. At the end of follow-up, 15 patients were obese and showed higher serum leptin and insulin levels than patients who did not gain weight. As in other types of obesity, elevation of serum leptin concentrations is related to the increase in body mass index.

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页码：230 / 232

页数：3

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