Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

被引：418

作者：

Plant, K

Pelkey, KA

Bortolotto, ZA

Morita, D

Terashima, A

McBain, CJ

Collingridge, GL

Isaac, JTR ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, MRC, Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

[2] NICHHD, Lab Cellular & Synapt Neurophysiol, NIH, Bethesda, MD 20892 USA

[3] NINDS, Dev Synapt Plast Unit, NIH, Bethesda, MD 20892 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nn1678

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lackingcalcium-permeable (CP)AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs similar to 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

引用

收藏

页码：602 / 604

页数：3

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