Antioxidant Therapy in Alzheimer's Disease: Theory and Practice

被引：131

作者：

Aliev, Gjumrakch ^{[2
,3
]}

Obrenovich, Mark E. ^{[4
]}

Reddy, V. Prakash ^{[7
]}

Shenk, Justin C. ^{[2
,3
]}

Moreira, Paula I. ^{[5
]}

Nunomura, Akihiko ^{[6
]}

Zhu, Xiongwei ^{[4
]}

Smith, Mark A. ^{[4
]}

Perry, George ^{[1
]}

机构：

[1] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA

[2] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA

[3] Univ Texas San Antonio, Electron Microscopy Res Ctr, San Antonio, TX 78249 USA

[4] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[5] Univ Coimbra, Ctr Neurosci & Cell Biol Coimbra, Coimbra, Portugal

[6] Asahikawa Med Coll, Dept Psychiat & Neurol, Asahikawa, Hokkaido 078, Japan

[7] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 13期

关键词：

Antioxidant; calorie restriction; estrogen; free radical; glutathione; oxidation; oxidative stress; therapy;

D O I：

10.2174/138955708786369582

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

引用

页码：1395 / 1406

页数：12

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