The Efficacy of Short-Term Interferon-Beta Therapy for Type C Cirrhotic Patients with Genotype 2a and Low Virus Load

被引：2

作者：

Arase, Yasuji ^{[1
]}

Suzuki, Fumitaka ^{[1
]}

Sezaki, Hitomi ^{[1
]}

Kawamura, Yusuke ^{[1
]}

Suzuki, Yoshiyuki ^{[1
]}

Kobayashi, Masahiro ^{[1
]}

Akuta, Norio ^{[1
]}

Hosaka, Tetsuya ^{[1
]}

Yatsuji, Hiromi ^{[1
]}

Kobayashi, Mariko ^{[2
]}

Saitoh, Satoshi ^{[1
]}

Ikeda, Kenji ^{[1
]}

Kumada, Hiromitsu ^{[1
]}

机构：

[1] Toranomon Gen Hosp, Dept Hepatol, Tokyo, Japan

[2] Toranomon Gen Hosp, Hepat Res Unit, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2008年 / 47卷 / 12期

关键词：

liver cirrhosis; hepatitis C virus; genotype; 2a; low virus load; interferon; sustained viral response;

D O I：

10.2169/internalmedicine.47.0886

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The aim of this study was to elucidate the efficacy of short-term interferon (IFN) therapy for type C cirrhotic patients with genotype 2a and low virus load. Methods The present study was retrospective cohort study. Inclusion criteria were liver cirrhosis, hepatitis C virus (HCV) genotype 2a, the serum HCV RNA level of less than 100 KIU/mL, and IFN period of 6 or 8 weeks. Twenty-five consecutive patients who satisfied the above criteria were treated with IFN-beta daily at the dosage of 6 MU for 6 or 8 weeks. Independent factors that might have influenced sustained virologic response (SVR) were studied using multiple logistic regression analysis. Results Background of clinical profiles were as follows: median (range) age=64 (53-76) years, male/female=13/12, and median (range) HCV-RNA=31 (8-90) KIU/mL. Out of 25, 14 patients (56.0%) had SVR by the intention-to-treat analysis. The SVR was significantly associated with serum HCV RNA level. Logistic analysis showed that SVR occurred when HCV RNA level was < 50 KIU/mL (p=0.047). Based on the difference of the serum HCV RNA level, the SVR rate was 68.4% (13/19) in patients with a serum HCV RNA level of < 50 KIU/mL and 16.7% (1/6) in patients with a serum HCV RNA level of >= 50 KIU/mL. Conclusions The 6 or 8-week IFN-beta therapy is a possible selection of therapy for cirrhotic patients with HCV genotype 2a and a serum HCV RNA level of < 50 KIU/mL.

引用

页码：1085 / 1090

页数：6

共 24 条

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