Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

被引：31

作者：

Comins, DL

Joseph, SP

Hong, H

Alawar, RS

Foti, CJ

Zhang, YM

Chen, XH

LaMunyon, DH

GuerraWeltzien, M

机构：

[1] Department of Chemistry, North Carolina State University, Raleigh

来源：

PURE AND APPLIED CHEMISTRY | 1997年 / 69卷 / 03期

关键词：

D O I：

10.1351/pac199769030477

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleophilic addition of organometallics to chiral 1-acylpyridinium salts occurs with high diastereoselectivity to give N-acyl-2,3-dihydro-4-pyridones, which are useful building blocks for the asymmetric synthesis of various alkaloids. The synthetic utility of these heterocycles lies in the ease of preparation and substitution. Our recent efforts at exploring the scope of this chemistry and its application towards the enantioselective synthesis of various alkaloids are described.

引用

页码：477 / 481

页数：5

共 18 条

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