Potent algicides based on the cyanobacterial alkaloid nostocarboline

被引：70

作者：

Blom, JF ^{[1
]}

Brütsch, T

Barbaras, D

Bethuel, Y

Locher, HH

Hubschwerlen, C

Gademann, K

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

[2] Univ Zurich, Inst Plant Biol, Limnol Sect, CH-8802 Kilchberg, Switzerland

[3] Actel Percurex AG, CH-4058 Basel, Switzerland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 04期

关键词：

D O I：

10.1021/ol052968b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >= 100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >= 0.7 mu M). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide.

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页码：737 / 740

页数：4

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