Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo

被引:53
作者
Polic, B
Jonjic, S
Pavic, I
Crnkovic, I
Zorica, I
Hengel, H
Lucin, P
Koszinowski, UH
机构
[1] UNIV HEIDELBERG,DEPT VIROL,D-69120 HEIDELBERG,GERMANY
[2] UNIV RIJEKA,FAC MED,DEPT PHYSIOL & IMMUNOL,RIJEKA 51000,CROATIA
关键词
D O I
10.1099/0022-1317-77-2-217
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
It has been claimed that MHC class I proteins serve as receptors for murine cytomegalovirus (MCMV) and that this interaction is the most important mechanism for virus entry in most cells. This claim is based on the observation that the MHC haplotype contributes to the susceptibility to cytomegalovirus (CMV) infection in vivo. Results from in vitro studies support the concept that stable expression of correctly folded MHC class I molecules contributes to infection, since the individual properties of MHC class I alleles, the availability of beta(2)-microglobulin (beta(2)m) and also the degree of peptide charging of the MHC class I heavy chain beta(2)m heterodimers determined the infection phenotype of cell lines. To assess the biological relevance of proper MHC class I expression we investigated CMV infection in beta(2)m-deficient mice which fail to express ternary MHC class I complexes and lack peripheral CD8(+) T lymphocytes. We found that organ virus titres and virus clearance kinetics were not altered in beta(2)m mutant mice. In addition, there was no indication of diminished virus propagation in beta(2)m(-/-) embryonic fibroblasts. beta(2)m(-/-) mice suffered from the lack of CD8(+) T lymphocytes that was partially compensated for by the function of CD4(+) T lymphocytes. An organ-specific anti-virus function of natural killer (NK) cells was observed, independent from the beta(2)m deletion. The immune control unique for salivary gland infection was maintained. From the data presented here, we confirm the role of MHC class I molecules in the immune surveillance of CMV infection but question the biological impact of correct MHC class I complexes for productive infection.
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页码:217 / 225
页数:9
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