Dendritic enlightenment:: Using patterned two-photon uncaging to reveal the secrets of the brain's smallest dendrites

被引：25

作者：

Judkewitz, B

Roth, A

Häusser, M

机构：

[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

[2] UCL, Dept Physiol, London WC1E 6BT, England

来源：

NEURON | 2006年 / 50卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2006.04.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been a longstanding challenge for experimentalists to manipulate precisely the spatial and temporal patterns of synaptic input to the dendritic tree in order to mimic activity occurring in the intact brain and determine their importance for synaptic integration. In this issue of Neuron, Losonczy and Magee have used rapid multisite two-photon uncaging of glutamate to define patterns of synaptic input on a submillisecond and micron scale to investigate the rules for summation of synaptic inputs in the fine oblique dendrites of pyramidal neurons.

引用

页码：180 / 183

页数：4

共 17 条

[1]

Ariav G, 2003, J NEUROSCI, V23, P7750

[2] Synaptic connectivity and neuronal morphology: Viewpoint two sides of the same coin [J].