New method of synthesis of Vinca alkaloid derivatives

被引：17

作者：

Fahy, J ^{[1
]}

du Boullay, VT ^{[1
]}

Bigg, DCH ^{[1
]}

机构：

[1] Ctr Rech Pierre Fabre, Div Chim Med 5, F-81106 Castres, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00784-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：505 / 507

页数：3

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