In the beginning: a viral origin exploits the cell

被引：11

作者：

Sugden, B ^{[1
]}

机构：

[1] Univ Wisconsin, McArdle Lab Canc Res, Madison, WI 53706 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(01)02032-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The origin of replication of Epstein-Barr Virus (EBV) has been shown to associate with cellular proteins that regulate the initiation of DNA synthesis in human cells. These cellular proteins are subunits of both the origin recognition complex and what might be the replicative helicase. Such associations identify the EBV origin of replication as being an experimentally tractable paradigm for mammalian replicons.

引用

页码：1 / 3

页数：3

共 19 条

[1] Start sites of bidirectional DNA synthesis at the human lamin B2 origin [J].

Abdurashidova, G ;

Deganuto, M ;

Klima, R ;

Riva, S ;

Biamonti, G ;

Giacca, M ;

Falaschi, A .

SCIENCE, 2000, 287 (5460) :2023-2026

[2] Components and dynamics of DNA replication complexes in S-cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase [J].

Aparicio, OM ;

Weinstein, DM ;

Bell, SP .

CELL, 1997, 91 (01) :59-69

[3]

Bogan JA, 2000, J CELL PHYSIOL, V184, P139, DOI 10.1002/1097-4652(200008)184:2<139::AID-JCP1>3.0.CO

[4]

2-8

[5] Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus [J].

Chaudhuri, B ;

Xu, HZ ;

Todorov, I ;

Dutta, A ;

Yates, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10085-10089

[6]

DePamphilis ML, 1996, DNA REPLICATION EUKA

[7] Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin [J].

Dhar, SK ;

Yoshida, K ;

Machida, Y ;

Khaira, P ;

Chaudhuri, B ;

Wohlschlegel, JA ;

Leffak, M ;

Yates, J ;

Dutta, A .

CELL, 2001, 106 (03) :287-296

[8]

FRAPPIER L, 1991, J BIOL CHEM, V266, P7819

[9] THE EPSTEIN-BARR VIRUS ORIGIN OF PLASMID REPLICATION, ORIP, CONTAINS BOTH THE INITIATION AND TERMINATION SITES OF DNA-REPLICATION [J].

GAHN, TA ;

SCHILDKRAUT, CL .

CELL, 1989, 58 (03) :527-535

[10] Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus [J].

Kirchmaier, AL ;

Sugden, B .

JOURNAL OF VIROLOGY, 1998, 72 (06) :4657-4666

← 1 2 →