Total synthesis of (+)-mycalamide A

被引：38

作者：

Kagawa, N ^{[1
]}

Ihara, M

Toyota, M

机构：

[1] Osaka Prefecture Univ, Grad Sch Sci, Dept Chem, Sakai, Osaka 5998531, Japan

[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808578, Japan

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 05期

关键词：

D O I：

10.1021/ol052943c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent total synthesis of (+)-mycalamide A is described. A Yb(OTf)(3)-TMSCI catalytic system is used to synthesize a trioxadecalin ring system, which contains the right segment of mycalamide A. In addition, a tetrallydropyran ring, which is the left segment, is constructed with use of a novel one-pot delta-lactonization protocol. Both segments are prepared from a common starting material, D-mannitol. These segments are then coupled and the functional groups are transformed to synthesize (+)-mycalamide A.

引用

页码：875 / 878

页数：4

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