DRB1*03 diversity and DRB3 associations in five major population groups in the United States

被引：19

作者：

Tang, TF

Wang, J

Slack, R

Lin, YS

Li, L

Heine, U

Ng, J

Hartzman, RJ

Hurley, CK

机构：

[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Pediat, Washington, DC 20007 USA

[3] Georgetown Univ, Med Ctr, Dept Biostat, Washington, DC 20007 USA

[4] Lab Corp Amer, Burlington, NC USA

[5] Naval Med Res Ctr, Bethesda, MD USA

来源：

HUMAN IMMUNOLOGY | 2002年 / 63卷 / 03期

关键词：

allele frequency; HLA-DR; DNA typing; allele combinations;

D O I：

10.1016/S0198-8859(01)00379-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One hundred sixty-one DRB1*03 positive individuals from each of Five U.S. population groups (Caucasoids, African Americans, Asians/Pacific Islanders, Hispanics, and Native Americans) were randomly selected from a database of 82,979 individuals. DRB1*03 alleles were identified by polymerase chain reaction-sequence-specific oligonucleotide probe typing. A total of six DRB1*03 alleles out of 21 known alleles were detected. DRB1*03011 was the predominant DRB1*03 allele in all populations. Caucasoids were found to be the least diversified; only DRB1*03011 was observed. African Americans carried DRB1*03021 at a high frequency. This allele was observed in three other populations. DRB1*0304 was found in Asians/Pacific Islanders and DRB1*0305, DRB1*0307 and a new allele, DRB1*0316, was found in Hispanics. A subset of individuals was also typed for DRB3 alleles. DRB3*0101, DRB3*0202, and DRB3*0301 were detected and seven DRB1-DRB3 haplotypes were defined. Testing of other individuals not included in the DRB1*03 frequency study identified a variation of a common extended haplotype, A1, B8, DR3, which carries DRB1*0304 and two previously unreported DRB1*03 alleles, DRB1*0311 and *0320, are also described. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.

引用

页码：221 / 228

页数：8

共 23 条

[1] IRREGULAR POLYMERASE CHAIN-REACTION SEQUENCE-SPECIFIC OLIGONUCLEOTIDE HYBRIDIZATION PATTERNS REVEAL 7 NEW HLA-DRB1 ALLELES RELATED TO DR2, DR3, DR6, DR8, AND DR11 - IMPLICATIONS FOR SEQUENCE-SPECIFIC PRIMING [J].

ANHOLTS, JDH ;

VERDUYN, W ;

PARLEVLIET, A ;

DOXIADIS, IIN ;

DAMARO, J ;

GIPHART, MJ ;

PERSIJN, GG ;

SCHREUDER, GMT .

HUMAN IMMUNOLOGY, 1995, 42 (01) :15-22

[2]

[Anonymous], 1983, Statistical methods

[3] 2 NEW HLA DRB1 ALLELES FOUND IN AFRICAN-AMERICANS - IMPLICATIONS FOR BALANCING SELECTION AT POSITION-57 AND POSITION-86 [J].

APPLE, RJ ;

ERLICH, HA .

TISSUE ANTIGENS, 1992, 40 (02) :69-74

[4] Identification of a new HLA-DR3 allele: DRB1*0305 [J].

Asu, UM ;

Taylor, M ;

Dunn, D ;

Fuller, TC .

TISSUE ANTIGENS, 1995, 46 (05) :405-407

[5] Nomenclature for factors of the HLA system, 1998 [J].

Bodmer, JG ;

Marsh, SGE ;

Albert, ED ;

Bodmer, WF ;

Bontrop, RE ;

Dupont, B ;

Erlich, HA ;

Hansen, JA ;

Mach, B ;

Mayr, WR ;

Parham, P ;

Petersdorf, EW ;

Sasazuki, T ;

Schreuder, GMT ;

Strominger, JL ;

Svejgaard, A ;

Terasaki, PI .

TISSUE ANTIGENS, 1999, 53 (04) :407-446

[6] High-resolution HLA class I typing in the CEPH families: analysis of linkage disequilibrium among HLA loci [J].

Bugawan, TL ;

Klitz, W ;

Blair, A ;

Erlich, HA .

TISSUE ANTIGENS, 2000, 56 (05) :392-404

[7] Diversity and evolution of the DRB1*03 family: Description of DRB1*03022, *0307, *0308 [J].

Ellis, JM ;

Steiner, N ;

Wang, J ;

Tang, TT ;

Hurley, CK .

TISSUE ANTIGENS, 1997, 49 (01) :41-45

[8] HLA-A*28 allele frequencies in the five major US ethnic groups [J].

Hsu, E ;

Bei, M ;

Slack, R ;

Hartzman, RJ ;

Ng, J ;

Hurley, CK .

HUMAN IMMUNOLOGY, 1999, 60 (02) :159-167

[9]

HURLEY CK, 1997, MANUAL CLIN LAB IMMU

[10] THE IMPACT OF NATURALLY-OCCURRING DR3 MICROVARIANTS, DRW17 AND DRW18, ON T-CELL ALLORECOGNITION [J].

JOHNSON, AH ;

TANG, TF ;

COWELL, V ;

HURLEY, CK .

HUMAN IMMUNOLOGY, 1991, 32 (01) :46-55

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