Vascular endothelial growth factor expression is increased in renal cell carcinoma

被引:140
作者
Nicol, D
Hii, SI
Walsh, M
Teh, B
Thompson, L
Kennett, C
Gotley, D
机构
[1] Department of Surgery, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD
[2] Princess Alexandra Hospital, Brisbane, QLD 4102, Ipswich Road
关键词
renal cell carcinoma; vascular endothelial growth factor; vascular permeability factor; Western blot; angiogenesis;
D O I
10.1016/S0022-5347(01)65028-6
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: To compare the expression of VEGF in renal cell carcinoma (RCC) and normal kidney. Materials and Methods: RT-PCR and Western blot analysis were performed on tumour and normal adjacent kidney collected from 31 patients (29 RCC and 2 oncocytomas) as well as proliferating vascular endothelial cells (VEC) in culture. Results: Expression of 3 VEGF isoforms was detected in normal renal parenchyma and all ROC by RT-PCR, but was not apparent in proliferating VEC. In 27 RCC, Western blot analysis demonstrated 3-37 fold increases in VEGF expression when compared to normal parenchyma. Immunohistochemistry demonstrated VEGF staining of both tumour cells and adjacent vascular endothelium. Normal kidney showed no staining for VEGF. In the 2 remaining RCC and both oncocytomas VEGF was not increased. Conclusions: VEGF expression is increased in RCC and may have a paracrine effect in these tumours in stimulating angiogenesis.
引用
收藏
页码:1482 / 1486
页数:5
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