The safety of acellular pertussis vaccine vs whole-cell pertussis vaccine - A postmarketing assessment

被引:61
作者
Rosenthal, S [1 ]
Chen, R [1 ]
Hadler, S [1 ]
机构
[1] CTR DIS CONTROL & PREVENT,NATL IMMUNIZATION PROGRAM,ATLANTA,GA 30341
来源
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE | 1996年 / 150卷 / 05期
关键词
D O I
10.1001/archpedi.1996.02170300011001
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To determine the impact of the introduction of acellular pertussis vaccine for the fourth and fifth doses of the diphtheria and tetanus toxoids and pertussis vaccine series in children on rates of reported vaccine-associated adverse events in the United States. Design: Analysis of postmarketing vaccine adverse event data from the Vaccine Adverse Event Reporting System during the years 1991 to 1993. Population Studied: Approximately 27 million doses of diphtheria and tetanus toxoids and pertussis vaccine and 5 million doses of diphtheria and tetanus toxoids and acellular pertussis vaccine were distributed from 1991 to 1993 to children 15 months to 7 years of age. Main Outcome Measures: Rates of reported fever, seizures, and hospitalizations after pertussis vaccination. Results: Rates of reported adverse events per 100 000 vaccinations were significantly lower after administration of diphtheria and tetanus toxoids and acellular pertussis vaccine than diphtheria and tetanus toxoids and pertussis vaccine for the following outcomes: all reports, 2.9 vs 9.8; fever, 1.9 vs 7.5; seizures, 0.5 vs 1.7; and hospitalizations, 0.2 vs 0.9. Conclusions: These results confirm that minor adverse events are less frequent after administration of the acellular pertussis vaccine. In addition, these data suggested that seizures and hospitalizations associated with pertussis vaccination are less frequent after administration of the acellular pertussis vaccine in age groups for which it is now recommended.
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页码:457 / 460
页数:4
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