Endothelin-1, delayed rectifier K channels, and pulmonary arterial smooth muscle

被引：16

作者：

Salter, KJ ^{[1
]}

Wilson, CM ^{[1
]}

Kato, K ^{[1
]}

Kozlowski, RZ ^{[1
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1998年 / 31卷

关键词：

endothelin-1; sarafotoxin S6c; K+ channels;

D O I：

10.1097/00005344-199800001-00026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sarafotoxin S6c [STXS6c; a selective endothelin-B (ETB) receptor agonist] causes constriction of isolated pulmonary arteries. In perforated-patch experiments on pulmonary arterial myocytes, ET-1 and STXS6c induced a gradual inhibition of the delayed rectifier K current (I-KV), the profile of which resembled that carried by Kv1.5. Reverse-transcriptase polymerase chain reaction (RT-PCR) experiments revealed mRNA encoding this channel, and immunolocalization experiments demonstrated expression of the channel protein in pulmonary arterial smooth muscle. It is tempting to speculate that ETB receptor coupling to Kv1.5 may be implicated in contraction after stimulation of these receptors.

引用

页码：S81 / S83

页数：3

共 6 条

[1] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR [J].