Reactive dienes: Intramolecular aromatic oxidation of 3-(2-hydroxyphenyl)-propionic acids

被引：68

作者：

Drutu, I ^{[1
]}

Njardarson, JT ^{[1
]}

Wood, JL ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, Sterling Chem Lab, New Haven, CT 06520 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 04期

关键词：

D O I：

10.1021/ol0169776

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 3-(2-hydroxyphenyl)-propionic acids with a hypervalent iodine reagent in the presence of a dienophile initiates a tandem intramolecular aromatic oxidation/Diels-Alder reaction. Herein we report (1) investigations on the scope and limitations of this novel reaction combination and (2) preliminary diastereoselectivity studies using alpha- and beta-substituted acids.

引用

页码：493 / 496

页数：4

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