What Have We Learned About Patients With Heart Failure and Preserved Ejection Fraction From DIG-PEF, CHARM-Preserved, and I-PRESERVE?

被引：134

作者：

Campbell, Ross T. ^{[1
]}

Jhund, Pardeep S.

Castagno, Davide ^{[2
]}

Hawkins, Nathaniel M. ^{[3
]}

Petrie, Mark C. ^{[4
]}

McMurray, John J. V.

机构：

[1] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland

[2] Univ Turin, Dept Cardiol, Dept Internal Med, Turin, Italy

[3] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[4] Golden Jubilee Natl Hosp, Glasgow, Lanark, Scotland

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2012年 / 60卷 / 23期

关键词：

heart failure; preserved ejection fraction; outcomes; reduced ejection fraction; VENTRICULAR SYSTOLIC FUNCTION; CONVERTING-ENZYME INHIBITORS; BRAIN NATRIURETIC PEPTIDE; HYPERTENSIVE PATIENTS; RANDOMIZED-TRIAL; CARDIOVASCULAR MORBIDITY; CLINICAL CHARACTERISTICS; MORTALITY; OUTCOMES; LIFE;

D O I：

10.1016/j.jacc.2012.04.064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Examination of patients with reduced and preserved ejection fraction in the DIG (Digitalis Investigation Group) trials and the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity) trials provides comparisons of outcomes in each of these types of heart failure. Comparison of the patients in these trials, along with the I-PRESERVE (Irbesartan in Heart Failure with Preserved Systolic Function Trial), with patients of similar age, sex distribution, and comorbidity in trials of hypertension, diabetes mellitus, angina pectoris, and atrial fibrillation provides even more interesting insights into the relation between phenotype and rates of death and heart failure hospitalization. The poor clinical outcomes in patients with heart failure and preserved ejection fraction do not seem easily explained on the basis of age, sex, comorbidity, blood pressure, or left ventricular structural remodeling but do seem to be explained by the presence of the syndrome of heart failure. (J Am Coll Cardiol 2012;60:2349-56) (C) 2012 by the American College of Cardiology Foundation

引用

页码：2349 / 2356

页数：8

共 47 条

[1] Effects of digoxin on morbidity and mortality in diastolic heart failure: The ancillary Digitalis Investigation Group trial [J].

Ahmed, Ali ;

Rich, Michael W. ;

Fleg, Jerome L. ;

Zile, Michael R. ;

Young, James B. ;

Kitzman, Dalane W. ;

Love, Thomas E. ;

Aronow, Wilbert S. ;

Adams, Kirkwood F., Jr. ;

Gheorghiade, Mihai .

CIRCULATION, 2006, 114 (05) :397-403

[2] Treatment of hypertension in patients 80 years of age or older [J].

Beckett, Nigel S. ;

Peters, Ruth ;

Fletcher, Astrid E. ;

Staessen, Jan A. ;

Liu, Lisheng ;

Dumitrascu, Dan ;

Stoyanovsky, Vassil ;

Antikainen, Riitta L. ;

Nikitin, Yuri ;

Anderson, Craig ;

Belhani, Alli ;

Forette, Francoise ;

Rajkumar, Chakravarthi ;

Thijs, Lutgarde ;

Banya, Winston ;

Bulpitt, Christopher J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (18) :1887-1898

[3] The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis [J].

Berry, C. ;

Doughty, R. N. ;

Granger, C. ;

Kober, L. ;

Massie, B. ;

McAlister, F. ;

McMurray, J. ;

Pocock, S. ;

Poppe, K. ;

Swedberg, K. ;

Somaratne, J. ;

Whalley, G. A. ;

Ahmed, A. ;

Andersson, B. ;

Bayes-Genis, A. ;

Berry, C. ;

Cowie, M. ;

Cubbon, R. ;

Doughty, R. N. ;

Ezekowitz, J. ;

Gonzalez-Juanatey, J. ;

Gorini, M. ;

Gotsman, I. ;

Grigorian-Shamagian, L. ;

Guazzi, M. ;

Kearney, M. ;

Kober, L. ;

Komajda, M. ;

di Lenarda, A. ;

Lenzen, M. ;

Lucci, D. ;

Macin, S. ;

Madsen, B. ;

Maggioni, A. ;

Martinez-Selles, M. ;

McAlister, F. ;

Oliva, F. ;

Poppe, K. ;

Rich, M. ;

Richards, M. ;

Senni, M. ;

Squire, I. ;

Taffet, G. ;

Tarantini, L. ;

Tribouilloy, C. ;

Troughton, R. ;

Tsutsui, H. ;

Whalley, G. A. ;

Doughty, R. N. ;

Earle, N. .

EUROPEAN HEART JOURNAL, 2012, 33 (14) :1750-1757

[4] Outcome of heart failure with preserved ejection fraction in a population-based study [J].

Bhatia, R. Sacha ;

Tu, Jack V. ;

Lee, Douglas S. ;

Austin, Peter C. ;

Fang, Jiming ;

Haouzi, Annick ;

Gong, Yanyan ;

Liu, Peter P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (03) :260-269

[5] Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study [J].

Caruana, L ;

Petrie, MC ;

Davie, AP ;

McMurray, JJV .

BRITISH MEDICAL JOURNAL, 2000, 321 (7255) :215-218

[6] Relationship between plasma concentrations of N-terminal pro brain natriuretic peptide and the characteristics and outcome of patients with a clinical diagnosis of diastolic heart failure: a report from the PEP-CHF study [J].

Cleland, John G. F. ;

Taylor, Jacqueline ;

Freemantle, Nick ;

Goode, Kevin M. ;

Rigby, Alan S. ;

Tendera, Michal .

EUROPEAN JOURNAL OF HEART FAILURE, 2012, 14 (05) :487-494

[7] Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol [J].

Dahlöf, B ;

Devereux, RB ;

Kjeldsen, SE ;

Julius, S ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Ibsen, H ;

Kristiansson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

LANCET, 2002, 359 (9311) :995-1003

[8] Characteristics of 9194 patients with left ventricular hypertrophy -: The LIFE study [J].

Dahlöf, B ;

Devereux, RB ;

Julius, S ;

Kjeldsen, SE ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Hedner, T ;

Ibsen, H ;

Kristianson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

HYPERTENSION, 1998, 32 (06) :989-997

[9] Echocardiographic left ventricular geometry in hypertensive patients with electrocardiographic left ventricular hypertrophy:: The LIFE study [J].

Devereux, RB ;

Bella, J ;

Boman, K ;

Gerdts, E ;

Nieminen, MS ;

Rokkedal, J ;

Papademetriou, V ;

Wachtell, K ;

Wright, J ;

Paranicas, M ;

Okin, PM ;

Roman, MJ ;

Smith, G ;

Dahlöf, B .

BLOOD PRESSURE, 2001, 10 (02) :74-82

[10] Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure - A report from the OPTIMIZE-HF registry [J].

Fonarow, Gregg C. ;

Stough, Wendy Gattis ;

Abraham, William T. ;

Albert, Nancy M. ;

Gheorghiade, Mihai ;

Greenberg, Barry H. ;

O'Connor, Christopher M. ;

Sun, Jie Lena ;

Yancy, Clyde W. ;

Young, James B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (08) :768-777

← 1 2 3 4 5 →